Bone morphogenetic protein-2 and-4 expression during murine orofacial development
JH Bennett, P Hunt, P Thorogood - Archives of oral biology, 1995 - Elsevier
In the developing orofacial region, epithelial-mesenchymal interactions induce a
differentiation cascade leading to bone and cartilage formation. Although the nature of this
interaction is unknown, bone morphogenetic proteins (BMP)-2 and-4 have been suggested
as putative signalling molecules. Using 35S-labelled cDNA probes, the expression patterns
of BMP-2 and-4 mRNA were examined in murine perioral tissues preceding, during and
following the time of the epithelial-mesenchymal interaction leading to mandibular formation …
differentiation cascade leading to bone and cartilage formation. Although the nature of this
interaction is unknown, bone morphogenetic proteins (BMP)-2 and-4 have been suggested
as putative signalling molecules. Using 35S-labelled cDNA probes, the expression patterns
of BMP-2 and-4 mRNA were examined in murine perioral tissues preceding, during and
following the time of the epithelial-mesenchymal interaction leading to mandibular formation …