[HTML][HTML] The MARCKS protein plays a critical role in phosphatidylinositol 4, 5-bisphosphate metabolism and directed cell movement in vascular endothelial cells
H Kalwa, T Michel - Journal of biological chemistry, 2011 - ASBMB
The MARCKS protein (myristoylated alanine-rich C kinase substrate) is an actin-and
calmodulin-binding protein that is expressed in many mammalian tissues. The role of
MARCKS in endothelial signaling responses is incompletely understood. We found that
siRNA-mediated knockdown of MARCKS in cultured endothelial cells abrogated directed
cell movement in a wound healing assay. We used biochemical and cell imaging
approaches to explore the role of MARCKS in endothelial signal transduction pathways …
calmodulin-binding protein that is expressed in many mammalian tissues. The role of
MARCKS in endothelial signaling responses is incompletely understood. We found that
siRNA-mediated knockdown of MARCKS in cultured endothelial cells abrogated directed
cell movement in a wound healing assay. We used biochemical and cell imaging
approaches to explore the role of MARCKS in endothelial signal transduction pathways …