[HTML][HTML] Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma
BS Paugh, A Broniscer, C Qu, CP Miller… - Journal of clinical …, 2011 - ncbi.nlm.nih.gov
Journal of clinical oncology, 2011•ncbi.nlm.nih.gov
Purpose Long-term survival for children with diffuse intrinsic pontine glioma (DIPG) is less
than 10%, and new therapeutic targets are urgently required. We evaluated a large cohort of
DIPGs to identify recurrent genomic abnormalities and gene expression signatures
underlying DIPG.
than 10%, and new therapeutic targets are urgently required. We evaluated a large cohort of
DIPGs to identify recurrent genomic abnormalities and gene expression signatures
underlying DIPG.
Abstract
Purpose
Long-term survival for children with diffuse intrinsic pontine glioma (DIPG) is less than 10%, and new therapeutic targets are urgently required. We evaluated a large cohort of DIPGs to identify recurrent genomic abnormalities and gene expression signatures underlying DIPG.
ncbi.nlm.nih.gov