[HTML][HTML] Glucocorticoid and cytokine crosstalk: Feedback, feedforward, and co-regulatory interactions determine repression or resistance
R Newton, S Shah, MO Altonsy, AN Gerber - Journal of Biological …, 2017 - ASBMB
Inflammatory signals induce feedback and feedforward systems that provide temporal
control. Although glucocorticoids can repress inflammatory gene expression, glucocorticoid
receptor recruitment increases expression of negative feedback and feedforward regulators,
including the phosphatase, DUSP1, the ubiquitin-modifying enzyme, TNFAIP3, or the mRNA-
destabilizing protein, ZFP36. Moreover, glucocorticoid receptor cooperativity with factors,
including nuclear factor-κB (NF-κB), may enhance regulator expression to promote …
control. Although glucocorticoids can repress inflammatory gene expression, glucocorticoid
receptor recruitment increases expression of negative feedback and feedforward regulators,
including the phosphatase, DUSP1, the ubiquitin-modifying enzyme, TNFAIP3, or the mRNA-
destabilizing protein, ZFP36. Moreover, glucocorticoid receptor cooperativity with factors,
including nuclear factor-κB (NF-κB), may enhance regulator expression to promote …