New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado–Joseph disease)
U Rüb, ER Brunt, T Deller - Current opinion in neurology, 2008 - journals.lww.com
U Rüb, ER Brunt, T Deller
Current opinion in neurology, 2008•journals.lww.comSystematic pathoanatomical analysis of spinocerebellar ataxia type 3 brains helps to
understand the structural basis of this neurodegenerative disease and offers explanations
for a variety of disease symptoms. This better understanding of the neuropathology of the
condition has implications for the treatment of spinocerebellar ataxia type 3 patients and
represents a basis for further biochemical and molecular biological studies aimed at
deciphering the pathomechanisms of this progressive ataxic disorder.
understand the structural basis of this neurodegenerative disease and offers explanations
for a variety of disease symptoms. This better understanding of the neuropathology of the
condition has implications for the treatment of spinocerebellar ataxia type 3 patients and
represents a basis for further biochemical and molecular biological studies aimed at
deciphering the pathomechanisms of this progressive ataxic disorder.
Summary
Systematic pathoanatomical analysis of spinocerebellar ataxia type 3 brains helps to understand the structural basis of this neurodegenerative disease and offers explanations for a variety of disease symptoms. This better understanding of the neuropathology of the condition has implications for the treatment of spinocerebellar ataxia type 3 patients and represents a basis for further biochemical and molecular biological studies aimed at deciphering the pathomechanisms of this progressive ataxic disorder.
Lippincott Williams & Wilkins