The kinetics and equilibria of the reactions of nitric oxide with sheep haemoglobin

QH Gibson, FJW Roughton - The Journal of physiology, 1957 - ncbi.nlm.nih.gov
QH Gibson, FJW Roughton
The Journal of physiology, 1957ncbi.nlm.nih.gov
In these equations jl, j2, j3 and j4 are the combination velocity constants, il, i2, j3, andj4 the
dissociation velocity constants and J1, J2, J3 and 34the equilibrium constants of the
corresponding intermediate reactions. During the early stages of combination of nitric oxide
with haemoglobin, the speed of the over-all process, which has proved to be faster than for
any previously measured haemoglobin-ligand combination, should be given approximately
by the equation d [NOHb]= j'[NO][Hb],(5) dt where
In these equations jl, j2, j3 and j4 are the combination velocity constants, il, i2, j3, andj4 the dissociation velocity constants and J1, J2, J3 and 34the equilibrium constants of the corresponding intermediate reactions. During the early stages of combination of nitric oxide with haemoglobin, the speed of the over-all process, which has proved to be faster than for any previously measured haemoglobin-ligand combination, should be given approximately by the equation d [NOHb]= j'[NO][Hb],(5) dt where
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