Advances in genomics have deepened our understanding of the biology of acute
lymphoblastic leukemia (ALL), defined novel molecular leukemia subtypes, discovered new
prognostic biomarkers and paved the way to emerging molecularly targeted therapeutic
avenues. Since its discovery, IKZF1 has generated significant interest within the leukemia
scientific community. IKZF1 plays a critical role in lymphoid development and its alterations
cooperate to mediate leukemogenesis. IKZF1 alterations are present in approximately 15 …