[HTML][HTML] Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition
FK Middleton, MJ Patterson, CJ Elstob, S Fordham… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Oncotarget, 2015•ncbi.nlm.nih.gov
ATRis an attractive target in cancer therapy because it signals replication stress and DNA
lesions for repair and to S/G2 checkpoints. Cancer-specific defects in the DNA damage
response (DDR) may render cancer cells vulnerable to ATR inhibition alone. We determined
the cytotoxicity of the ATR inhibitor VE-821 in isogenically matched cells with DDR
imbalance. Cell cycle arrest, DNA damage accumulation and repair were determined
following VE-821 exposure.
lesions for repair and to S/G2 checkpoints. Cancer-specific defects in the DNA damage
response (DDR) may render cancer cells vulnerable to ATR inhibition alone. We determined
the cytotoxicity of the ATR inhibitor VE-821 in isogenically matched cells with DDR
imbalance. Cell cycle arrest, DNA damage accumulation and repair were determined
following VE-821 exposure.
Abstract
ATRis an attractive target in cancer therapy because it signals replication stress and DNA lesions for repair and to S/G2 checkpoints. Cancer-specific defects in the DNA damage response (DDR) may render cancer cells vulnerable to ATR inhibition alone. We determined the cytotoxicity of the ATR inhibitor VE-821 in isogenically matched cells with DDR imbalance. Cell cycle arrest, DNA damage accumulation and repair were determined following VE-821 exposure.
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