Importance There is increasing evidence that Parkinson disease (PD) is heterogeneous in
its clinical presentation and prognosis. Defining subtypes of PD is needed to better
understand underlying mechanisms, predict disease course, and eventually design more
efficient personalized management strategies. Objectives To identify clinical subtypes of PD,
compare the prognosis and progression rate between PD phenotypes, and compare the
ability to predict prognosis in our subtypes and those from previously published clustering …