Pellino-1 promotes intrinsic activation of skin-resident IL-17A–producing T cells in psoriasis
SH Kim, J Oh, WS Roh, J Park, KB Chung… - Journal of Allergy and …, 2023 - Elsevier
Background Psoriasis is a chronically relapsing inflammatory skin disease primarily
perpetuated by skin-resident IL-17–producing T (T17) cells. Pellino-1 (Peli1) belongs to a
member of E3 ubiquitin ligase mediating immune receptor signaling cascades, including
nuclear factor kappa–light-chain enhancer of activated B cells (NF-κB) pathway. Objective
We explored the potential role of Peli1 in psoriatic inflammation in the context of skin-
resident T17 cells. Methods We performed single-cell RNA sequencing of relapsing and …
perpetuated by skin-resident IL-17–producing T (T17) cells. Pellino-1 (Peli1) belongs to a
member of E3 ubiquitin ligase mediating immune receptor signaling cascades, including
nuclear factor kappa–light-chain enhancer of activated B cells (NF-κB) pathway. Objective
We explored the potential role of Peli1 in psoriatic inflammation in the context of skin-
resident T17 cells. Methods We performed single-cell RNA sequencing of relapsing and …