Effects of genetic variation in protease activated receptor 4 after an acute coronary syndrome: analysis from the TRACER trial
P Tricoci, M Neely, MJ Whitley, LC Edelstein… - Blood Cells, Molecules …, 2018 - Elsevier
Variation in platelet response to thrombin may affect the safety and efficacy of PAR
antagonism. The Thr120 variant of the common single nucleotide polymorphism (SNP)
rs773902 in the protease-activated receptor (PAR) 4 gene is associated with higher platelet
aggregation compared to the Ala120 variant. We investigated the relationship between the
rs773902 SNP with major bleeding and ischemic events, safety, and efficacy of PAR1
inhibition in 6177 NSTE ACS patients in the TRACER trial. There was a lower rate of GUSTO …
antagonism. The Thr120 variant of the common single nucleotide polymorphism (SNP)
rs773902 in the protease-activated receptor (PAR) 4 gene is associated with higher platelet
aggregation compared to the Ala120 variant. We investigated the relationship between the
rs773902 SNP with major bleeding and ischemic events, safety, and efficacy of PAR1
inhibition in 6177 NSTE ACS patients in the TRACER trial. There was a lower rate of GUSTO …