[HTML][HTML] Hyperglycemia exacerbates ischemic stroke outcome independent of platelet glucose uptake
F Denorme, I Portier, Y Kosaka, RA Campbell - Journal of thrombosis and …, 2021 - Elsevier
Objective Hyperglycemia is a common comorbidity for ischemic stroke and is associated
with worsened neurological outcomes. Platelets are central mediators of ischemic stroke
and hyperglycemia mediates platelet hyperactivity. In this study, we investigated the
contribution of platelet glucose metabolism to ischemic stroke. Methods Mice lacking both
Glut1 and Glut3 specifically in platelets (DKO) and their littermate controls (WT) were
subjected to 1‐hour transient middle cerebral artery occlusion under normoglycemic and …
with worsened neurological outcomes. Platelets are central mediators of ischemic stroke
and hyperglycemia mediates platelet hyperactivity. In this study, we investigated the
contribution of platelet glucose metabolism to ischemic stroke. Methods Mice lacking both
Glut1 and Glut3 specifically in platelets (DKO) and their littermate controls (WT) were
subjected to 1‐hour transient middle cerebral artery occlusion under normoglycemic and …