Receiver-operating characteristic analysis for evaluating diagnostic tests and predictive models

KH Zou, AJ O'Malley, L Mauri - Circulation, 2007 - Am Heart Assoc
KH Zou, AJ O'Malley, L Mauri
Circulation, 2007Am Heart Assoc
When evaluating a continuous-scale diagnostic test, we need to account for the changes of
specificity and sensitivity when the test threshold t varies. One may wish to report the sum of
sensitivity and specificity at the optimal threshold (discussed later in greater detail).
However, because the optimal value of t may not be relevant to a particular application, it
can be helpful to plot sensitivity and specificity over a range of values of interest, as is done
with an ROC curve. This inherent tradeoff between sensitivity and specificity also can be …
When evaluating a continuous-scale diagnostic test, we need to account for the changes of specificity and sensitivity when the test threshold t varies. One may wish to report the sum of sensitivity and specificity at the optimal threshold (discussed later in greater detail). However, because the optimal value of t may not be relevant to a particular application, it can be helpful to plot sensitivity and specificity over a range of values of interest, as is done with an ROC curve. This inherent tradeoff between sensitivity and specificity also can be demonstrated by varying the choice of threshold.
Am Heart Assoc