Antidepressants are commonly used in substance abusers due to the potential effect on
some underlying mechanisms involved in drug use disorders and to treat comorbid
depression. A systematic review of the literature of the efficacy of antidepressant drugs in
subjects with drug abuse disorders, including alcohol, cocaine, nicotine and opioid, with and
without comorbid depression was performed. Only randomised, double-blind, controlled
trials have been evaluated. A meta-analysis was done with the included studies that used …