Emerging role for nucleus accumbens medium spiny neuron subtypes in depression
TC Francis, MK Lobo - Biological psychiatry, 2017 - Elsevier
The ventral striatum (nucleus accumbens) and its role in mood, reward, and motivation has
been the focus of significant research. Despite this interest, little work has addressed cell
type–specific distinctions in medium spiny neurons (MSNs), the main projection neurons in
the nucleus accumbens and dorsal striatum, and their function in relation to stress and
depression. Previous work has shown opposing roles for D 1 and D 2 receptor MSN
subtypes in depression-like outcomes to stress, particularly in regard to repeated neuronal …
been the focus of significant research. Despite this interest, little work has addressed cell
type–specific distinctions in medium spiny neurons (MSNs), the main projection neurons in
the nucleus accumbens and dorsal striatum, and their function in relation to stress and
depression. Previous work has shown opposing roles for D 1 and D 2 receptor MSN
subtypes in depression-like outcomes to stress, particularly in regard to repeated neuronal …