Both classic Gs-cAMP/PKA/CREB and alternative Gs-cAMP/PKA/p38β/CREB signal pathways mediate exenatide-stimulated expression of M2 microglial markers
HY Wu, XQ Tang, H Liu, XF Mao, YX Wang - Journal of neuroimmunology, 2018 - Elsevier
GLP-1 receptor agonists, exenatide and GLP-1, promoted M2 type polarization in
monocytes/macrophages and microglial cells. This study explored the signal basis
underlying exenatide-stimulated expression of M2 microglia-specific genes, including the
cytoplasmic marker Arg 1, surface marker CD206, and secretion protein marker IL-4.
Treatment with exenatide in cultured primary microglial cells concentration dependently
stimulated the expression of Arg 1, CD206 and IL-4, but did not significantly alter LPS …
monocytes/macrophages and microglial cells. This study explored the signal basis
underlying exenatide-stimulated expression of M2 microglia-specific genes, including the
cytoplasmic marker Arg 1, surface marker CD206, and secretion protein marker IL-4.
Treatment with exenatide in cultured primary microglial cells concentration dependently
stimulated the expression of Arg 1, CD206 and IL-4, but did not significantly alter LPS …