Some consequences of capillary permeability to macromolecules: Starling's hypothesis reconsidered
EM Renkin - American Journal of Physiology-Heart and …, 1986 - journals.physiology.org
EM Renkin
American Journal of Physiology-Heart and Circulatory Physiology, 1986•journals.physiology.orgStarling's hypothesis ascribes fluid movements across capillary walls to the interaction of
hydrostatic and colloid osmotic forces. For 90 years it has been recognized as the basis of
plasma-to-interstitial fluid balance. Its original statement was based on the notion of capillary
impermeability to plasma proteins. However, as knowledge of transcapillary exchange of
plasma proteins developed, its formulation was progressively modified to allow for protein
transport and for interaction of protein transport with volume flow. The most important …
hydrostatic and colloid osmotic forces. For 90 years it has been recognized as the basis of
plasma-to-interstitial fluid balance. Its original statement was based on the notion of capillary
impermeability to plasma proteins. However, as knowledge of transcapillary exchange of
plasma proteins developed, its formulation was progressively modified to allow for protein
transport and for interaction of protein transport with volume flow. The most important …
Starling's hypothesis ascribes fluid movements across capillary walls to the interaction of hydrostatic and colloid osmotic forces. For 90 years it has been recognized as the basis of plasma-to-interstitial fluid balance. Its original statement was based on the notion of capillary impermeability to plasma proteins. However, as knowledge of transcapillary exchange of plasma proteins developed, its formulation was progressively modified to allow for protein transport and for interaction of protein transport with volume flow. The most important aspects of the conceptual evolution of Starling's hypothesis are reviewed in the text of this lecture.
American Physiological Society