Sildenafil in severe pulmonary hypertension associated with chronic obstructive pulmonary disease: a randomized controlled multicenter clinical trial
P Vitulo, A Stanziola, M Confalonieri… - The Journal of Heart and …, 2017 - Elsevier
Background Pulmonary hypertension (PH) is a well-known independent prognostic factor in
chronic obstructive pulmonary disease (COPD) and a sufficient criterion for lung transplant
candidacy. Limited data are currently available on the hemodynamic and clinical effect of
phosphodiesterase 5 inhibitors in patients with severe PH associated with COPD. This study
assessed the effect of sildenafil on pulmonary hemodynamics and gas exchange in severe
PH associated with COPD. Methods After screening, this multicenter, randomized, placebo …
chronic obstructive pulmonary disease (COPD) and a sufficient criterion for lung transplant
candidacy. Limited data are currently available on the hemodynamic and clinical effect of
phosphodiesterase 5 inhibitors in patients with severe PH associated with COPD. This study
assessed the effect of sildenafil on pulmonary hemodynamics and gas exchange in severe
PH associated with COPD. Methods After screening, this multicenter, randomized, placebo …