Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis
NKJ Adhikari, RP Dellinger, S Lundin… - Critical care …, 2014 - journals.lww.com
Objective: Treatment with inhaled nitric oxide improves oxygenation but not survival in
mechanically ventilated patients with acute respiratory distress syndrome, but the effect may
depend on the severity of hypoxemia. Our objective was to determine whether nitric oxide
reduces hospital mortality in patients with severe acute respiratory distress syndrome (PaO
2/FIO 2≤ 100 mm Hg) but not in patients with mild-moderate acute respiratory distress
syndrome (100< PaO 2/FIO 2≤ 300 mm Hg) at the time of randomization. Data Sources …
mechanically ventilated patients with acute respiratory distress syndrome, but the effect may
depend on the severity of hypoxemia. Our objective was to determine whether nitric oxide
reduces hospital mortality in patients with severe acute respiratory distress syndrome (PaO
2/FIO 2≤ 100 mm Hg) but not in patients with mild-moderate acute respiratory distress
syndrome (100< PaO 2/FIO 2≤ 300 mm Hg) at the time of randomization. Data Sources …