[HTML][HTML] Pulmonary vascular involvement in chronic obstructive pulmonary disease. Is there a pulmonary vascular phenotype?
American journal of respiratory and critical care medicine, 2018•atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a multifaceted disease in which the
pulmonary vessels are often affected (1, 2). Mild pulmonary hypertension (PH) is a common
feature of COPD and may result from elevated vascular resistance, increased filling
pressures of the left ventricle, or elevated intrathoracic pressure caused by air trapping.
However, a subset of patients may develop severe precapillary PH and present with specific
clinical features, including moderate airway obstruction and severe limitation of DLCO …
pulmonary vessels are often affected (1, 2). Mild pulmonary hypertension (PH) is a common
feature of COPD and may result from elevated vascular resistance, increased filling
pressures of the left ventricle, or elevated intrathoracic pressure caused by air trapping.
However, a subset of patients may develop severe precapillary PH and present with specific
clinical features, including moderate airway obstruction and severe limitation of DLCO …
Chronic obstructive pulmonary disease (COPD) is a multifaceted disease in which the pulmonary vessels are often affected (1, 2). Mild pulmonary hypertension (PH) is a common feature of COPD and may result from elevated vascular resistance, increased filling pressures of the left ventricle, or elevated intrathoracic pressure caused by air trapping. However, a subset of patients may develop severe precapillary PH and present with specific clinical features, including moderate airway obstruction and severe limitation of DLCO, which, for the purpose of this concept paper, we call the pulmonary vascular phenotype. This perspective 1) reviews the most updated concepts of pulmonary vascular changes in COPD and 2) discusses the evidence gaps, unmet needs, and current research questions regarding the pulmonary vascular phenotype.
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