Importance Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder
characterized by loss of upper and lower motor neurons. Although novel ALS genetic
variants have been identified, the shared genetic risk between ALS and other
neurodegenerative disorders remains poorly understood. Objectives To examine whether
there are common genetic variants that determine the risk for ALS and other
neurodegenerative diseases and to identify their functional pathways. Design, Setting, and …