[HTML][HTML] Friend or foe—Post-translational modifications as regulators of phase separation and RNP granule dynamics
M Hofweber, D Dormann - Journal of Biological Chemistry, 2019 - ASBMB
Ribonucleoprotein (RNP) granules are membrane-less organelles consisting of RNA-
binding proteins (RBPs) and RNA. RNA granules form through liquid–liquid phase
separation (LLPS), whereby weak promiscuous interactions among RBPs and/or RNAs
create a dense network of interacting macromolecules and drive the phase separation. Post-
translational modifications (PTMs) of RBPs have emerged as important regulators of LLPS
and RNP granule dynamics, as they can directly weaken or enhance the multivalent …
binding proteins (RBPs) and RNA. RNA granules form through liquid–liquid phase
separation (LLPS), whereby weak promiscuous interactions among RBPs and/or RNAs
create a dense network of interacting macromolecules and drive the phase separation. Post-
translational modifications (PTMs) of RBPs have emerged as important regulators of LLPS
and RNP granule dynamics, as they can directly weaken or enhance the multivalent …
