[HTML][HTML] Myricetin slows liquid–liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity
B Dai, T Zhong, ZX Chen, W Chen, N Zhang… - Journal of Biological …, 2021 - ASBMB
Intraneuronal neurofibrillary tangles composed of Tau aggregates have been widely
accepted as an important pathological hallmark of Alzheimer's disease. A current
therapeutic avenue for treating Alzheimer's disease is aimed at inhibiting Tau accumulation
with small molecules such as natural flavonoids. Liquid–liquid phase separation (LLPS) of
Tau can lead to its aggregation, and Tau aggregates can then be degraded by autophagy.
However, it is unclear whether natural flavonoids modulate the formation of phase …
accepted as an important pathological hallmark of Alzheimer's disease. A current
therapeutic avenue for treating Alzheimer's disease is aimed at inhibiting Tau accumulation
with small molecules such as natural flavonoids. Liquid–liquid phase separation (LLPS) of
Tau can lead to its aggregation, and Tau aggregates can then be degraded by autophagy.
However, it is unclear whether natural flavonoids modulate the formation of phase …
