Key role of the positive feedback between PGE2 and COX2 in the biology of myeloid-derived suppressor cells
N Obermajer, P Kalinski - Oncoimmunology, 2012 - Taylor & Francis
N Obermajer, P Kalinski
Oncoimmunology, 2012•Taylor & FrancisPGE2 is the key factor needed for MDSCs development, accumulation and functional
stability. PGE2 initiates an EP2/EP4-mediated positive feedback between COX2 and PGE2
in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2-or
EP2/EP4-blockade abrogates MDSC functions and their CXCR4-CXCL12-mediated
attraction to cancer environment, providing convenient immunotherapeutic targets.
stability. PGE2 initiates an EP2/EP4-mediated positive feedback between COX2 and PGE2
in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2-or
EP2/EP4-blockade abrogates MDSC functions and their CXCR4-CXCL12-mediated
attraction to cancer environment, providing convenient immunotherapeutic targets.
PGE2 is the key factor needed for MDSCs development, accumulation and functional stability. PGE2 initiates an EP2/EP4-mediated positive feedback between COX2 and PGE2 in monocytic precursors, redirecting dendritic cell differentiation to MDSCs. COX2- or EP2/EP4- blockade abrogates MDSC functions and their CXCR4-CXCL12-mediated attraction to cancer environment, providing convenient immunotherapeutic targets.
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