Increased risk for frontotemporal dementia through interaction between tau polymorphisms and apolipoprotein E∊ 4
M Ingelson, SF Fabre, L Lilius, C Andersen… - …, 2001 - journals.lww.com
The tau gene has an important role in frontotemporal dementia (FTD) as pathogenic
mutations have been found in hereditary forms of the disease. Furthermore, a certain
extended tau haplotype has been shown to increase the risk for progressive supranuclear
palsy, corticobasal degeneration, Parkinson's disease and, in interaction with the
apolipoprotein E (apoE)∊ 4 allele, Alzheimer's disease. By microsatellite analysis we
investigated an intronic tau polymorphism, in linkage disequilibrium with the extended tau …
mutations have been found in hereditary forms of the disease. Furthermore, a certain
extended tau haplotype has been shown to increase the risk for progressive supranuclear
palsy, corticobasal degeneration, Parkinson's disease and, in interaction with the
apolipoprotein E (apoE)∊ 4 allele, Alzheimer's disease. By microsatellite analysis we
investigated an intronic tau polymorphism, in linkage disequilibrium with the extended tau …