Synthetic peptide immunogens that mimic the conformation of a target epitope of
pathological relevance offer the possibility to precisely control the immune response
specificity. Here, we performed conformational analyses using a panel of peptides in order
to investigate the key parameters controlling their conformation upon integration into
liposomal bilayers. These revealed that the peptide lipidation pattern, the lipid anchor chain
length, and the liposome surface charge all significantly alter peptide conformation. Peptide …