Reactions to multiple ascending doses of the microtubule stabilizer TPI-287 in patients with Alzheimer disease, progressive supranuclear palsy, and corticobasal …
RM Tsai, Z Miller, M Koestler, JC Rojas… - JAMA …, 2020 - jamanetwork.com
Importance Basket-design clinical trials that allow investigation of treatment effects on
different clinical syndromes that share the same molecular pathophysiology have not
previously been attempted in neurodegenerative disease. Objective To assess the safety,
tolerability, and pharmacodynamics of the microtubule stabilizer TPI-287 (abeotaxane) in
Alzheimer disease (AD) or the 4-repeat tauopathies (4RT) progressive supranuclear palsy
(PSP) and corticobasal syndrome (CBS). Design, Setting, and Participants Two parallel …
different clinical syndromes that share the same molecular pathophysiology have not
previously been attempted in neurodegenerative disease. Objective To assess the safety,
tolerability, and pharmacodynamics of the microtubule stabilizer TPI-287 (abeotaxane) in
Alzheimer disease (AD) or the 4-repeat tauopathies (4RT) progressive supranuclear palsy
(PSP) and corticobasal syndrome (CBS). Design, Setting, and Participants Two parallel …