[HTML][HTML] Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles
K Taniguchi, R Takeya, S Suetsugu, M Kan-o… - Journal of Biological …, 2009 - ASBMB
Actin filament assembly in nonmuscle cells is regulated by the actin polymerization
machinery, including the Arp2/3 complex and formins. However, little is known about the
regulation of actin assembly in muscle cells, where straight actin filaments are organized
into the contractile unit sarcomere. Here, we show that Fhod3, a myocardial formin that
localizes to thin actin filaments in a striated pattern, regulates sarcomere organization in
cardiomyocytes. RNA interference-mediated depletion of Fhod3 results in a marked …
machinery, including the Arp2/3 complex and formins. However, little is known about the
regulation of actin assembly in muscle cells, where straight actin filaments are organized
into the contractile unit sarcomere. Here, we show that Fhod3, a myocardial formin that
localizes to thin actin filaments in a striated pattern, regulates sarcomere organization in
cardiomyocytes. RNA interference-mediated depletion of Fhod3 results in a marked …