[HTML][HTML] Inhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy
M Yakabe, S Ogawa, H Ota, K Iijima, M Eto, Y Ouchi… - PLoS …, 2018 - journals.plos.org
M Yakabe, S Ogawa, H Ota, K Iijima, M Eto, Y Ouchi, M Akishita
PLoS One, 2018•journals.plos.orgBackground Interleukin-6 (IL-6) is an inflammatory cytokine. Whether systemic IL-6 affects
atrogene expression and disuse-induced skeletal muscle atrophy is unclear. Methods Tail-
suspended mice were used as a disuse-induced muscle atrophy model. We administered
anti-mouse IL-6 receptor antibody, beta-hydroxy-beta-methylbutyrate (HMB) and vitamin D
to the mice and examined the effects on atrogene expression and muscle atrophy. Results
Serum IL-6 levels were elevated in the mice. Inhibition of IL-6 receptor suppressed muscle …
atrogene expression and disuse-induced skeletal muscle atrophy is unclear. Methods Tail-
suspended mice were used as a disuse-induced muscle atrophy model. We administered
anti-mouse IL-6 receptor antibody, beta-hydroxy-beta-methylbutyrate (HMB) and vitamin D
to the mice and examined the effects on atrogene expression and muscle atrophy. Results
Serum IL-6 levels were elevated in the mice. Inhibition of IL-6 receptor suppressed muscle …
Background
Interleukin-6 (IL-6) is an inflammatory cytokine. Whether systemic IL-6 affects atrogene expression and disuse-induced skeletal muscle atrophy is unclear.
Methods
Tail-suspended mice were used as a disuse-induced muscle atrophy model. We administered anti-mouse IL-6 receptor antibody, beta-hydroxy-beta-methylbutyrate (HMB) and vitamin D to the mice and examined the effects on atrogene expression and muscle atrophy.
Results
Serum IL-6 levels were elevated in the mice. Inhibition of IL-6 receptor suppressed muscle RING finger 1 (MuRF1) expression and prevented muscle atrophy. HMB and vitamin D inhibited the serum IL-6 surge, downregulated the expression of MuRF1 and atrogin-1 in the soleus muscle, and ameliorated atrophy in the mice.
Conclusion
Systemic IL-6 affects MuRF1 expression and disuse-induced muscle atrophy.
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