Therapeutic effects of artesunate on lupus-prone MRL/lpr mice are dependent on T follicular helper cell differentiation and activation of JAK2–STAT3 signaling …
WZ Dang, H Li, B Jiang, KS Nandakumar, KF Liu… - Phytomedicine, 2019 - Elsevier
Background Anti-malarial drug artesunate (ART), a semi-synthetic derivative of artemisnin,
has immunosuppressive effects on several autoimmune diseases, including Systemic lupus
erythematosus (SLE), Rheumatoid arthritis (RA), and Colitis. However, molecular
mechanisms of ART, especially on follicular helper T cells (Tfh), central players in SLE
pathology, are far from clear. Purpose The object for this work is to investigate the
therapeutic effect of ART on lupus-prone MRL/lpr mice and its regulatory function on Tfh …
has immunosuppressive effects on several autoimmune diseases, including Systemic lupus
erythematosus (SLE), Rheumatoid arthritis (RA), and Colitis. However, molecular
mechanisms of ART, especially on follicular helper T cells (Tfh), central players in SLE
pathology, are far from clear. Purpose The object for this work is to investigate the
therapeutic effect of ART on lupus-prone MRL/lpr mice and its regulatory function on Tfh …
