Increased frequency of circulating follicular helper T cells in lupus patients is associated with autoantibody production in a CD40L-dependent manner
H Xu, J Liu, X Cui, Y Zuo, Z Zhang, Y Li, R Tao, Y Li… - Cellular …, 2015 - Elsevier
This study was to determine the frequency of circulating follicular helper T (Tfh) cells in
patients with systemic lupus erythematosus (SLE) and investigate the relationship between
Tfh cells and autoantibody production. An increased frequency of circulating Tfh cells was
found in SLE patients, and there were positive co-relationship between Tfh cells and
SLEDAI, serum IgG, Anti-nuclear antibody titers and anti-dsDNA (P= 0.0004, 0.0006, 0.0237,
0.0000, respectively). B cells sorted from SLE patients produced more IgG than healthy …
patients with systemic lupus erythematosus (SLE) and investigate the relationship between
Tfh cells and autoantibody production. An increased frequency of circulating Tfh cells was
found in SLE patients, and there were positive co-relationship between Tfh cells and
SLEDAI, serum IgG, Anti-nuclear antibody titers and anti-dsDNA (P= 0.0004, 0.0006, 0.0237,
0.0000, respectively). B cells sorted from SLE patients produced more IgG than healthy …