Downregulation of BDH2 modulates iron homeostasis and promotes DNA demethylation in CD4+ T cells of systemic lupus erythematosus
M Zhao, M Li, X Gao, S Jia, K Gao, Y Zhou, H Zhang… - Clinical …, 2018 - Elsevier
DNA hypomethylation plays an important role in the pathogenesis of systemic lupus
erythematosus (SLE). Here we investigated whether 3-hydroxy butyrate dehydrogenase 2
(BDH2), a modulator of intracellular iron homeostasis, was involved in regulating DNA
hypomethylation and hyper-hydroxymethylation in lupus CD4+ T cells. Our results showed
that BDH2 expression was decreased, intracellular iron was increased, global DNA
hydroxymethylation level was elevated, while methylation level was reduced in lupus CD4+ …
erythematosus (SLE). Here we investigated whether 3-hydroxy butyrate dehydrogenase 2
(BDH2), a modulator of intracellular iron homeostasis, was involved in regulating DNA
hypomethylation and hyper-hydroxymethylation in lupus CD4+ T cells. Our results showed
that BDH2 expression was decreased, intracellular iron was increased, global DNA
hydroxymethylation level was elevated, while methylation level was reduced in lupus CD4+ …