[HTML][HTML] Genetically predicted serum iron status is associated with altered risk of systemic lupus erythematosus among European populations
D Ye, Z Zhu, H Huang, X Sun, B Liu, X Xu, Z He… - The Journal of …, 2021 - Elsevier
Background Observational epidemiological studies have reported an inconsistent relation
between iron status and risk of systemic lupus erythematosus (SLE). Moreover, it remains
uncertain whether the observed association is causal or due to confounding or reverse
causality. Objectives We aimed to investigate the association between serum iron status and
risk of SLE using a 2-sample Mendelian randomization (MR) approach. Methods Genetic
instruments for iron status including serum iron, log-transformed ferritin, transferrin …
between iron status and risk of systemic lupus erythematosus (SLE). Moreover, it remains
uncertain whether the observed association is causal or due to confounding or reverse
causality. Objectives We aimed to investigate the association between serum iron status and
risk of SLE using a 2-sample Mendelian randomization (MR) approach. Methods Genetic
instruments for iron status including serum iron, log-transformed ferritin, transferrin …