[PDF][PDF] Why is there so much CD45 on T cells?
R Zamoyska - Immunity, 2007 - cell.com
R Zamoyska
Immunity, 2007•cell.comPreviews Page 1 viruses. The abundant secretion of type I interferon might activate NOX2 or
other components of the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase
system, which produces reactive oxygen intermediates (ROIs). ROIs reduce endosomal pH,
which in turn prevents complete degradation of the antigen and thereby enhances antigen
crosspresentation (Savina et al., 2006). Although human pDCs do not express mannose receptor,
a C type lectin that favors crosspresentation by enabling antigen uptake into specialized …
other components of the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase
system, which produces reactive oxygen intermediates (ROIs). ROIs reduce endosomal pH,
which in turn prevents complete degradation of the antigen and thereby enhances antigen
crosspresentation (Savina et al., 2006). Although human pDCs do not express mannose receptor,
a C type lectin that favors crosspresentation by enabling antigen uptake into specialized …
The balance between kinases and phosphatases is crucial for regulating lymphocyte signaling. In this issue, McNeill et al. (2007) show that the transmembrane phosphatase CD45 has a role as both positive and negative regulator of T cell signaling.
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