Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes.
BG Slavin, JM Ong, PA Kern - Journal of lipid research, 1994 - ASBMB
Hormone-sensitive lipase (HSL) mediates the lipolysis of triacylglycerol from mammalian
adipocytes, resulting in the release of non-esterified fatty acids and glycerol. Although
numerous studies have examined the hormonal regulation of HSL, the measurement of HSL
mRNA levels in response to hormonal regulators has not been studied. This study was
designed to determine the effects of epinephrine, growth hormone, glucagon, and
dexamethasone on HSL expression by measuring HSL mRNA levels and glycerol release in …
adipocytes, resulting in the release of non-esterified fatty acids and glycerol. Although
numerous studies have examined the hormonal regulation of HSL, the measurement of HSL
mRNA levels in response to hormonal regulators has not been studied. This study was
designed to determine the effects of epinephrine, growth hormone, glucagon, and
dexamethasone on HSL expression by measuring HSL mRNA levels and glycerol release in …