T cells in systemic lupus erythematosus
A Suárez-Fueyo, SJ Bradley, GC Tsokos - Current opinion in immunology, 2016 - Elsevier
A Suárez-Fueyo, SJ Bradley, GC Tsokos
Current opinion in immunology, 2016•ElsevierHighlights•T cell transcriptomes can stratify patients.•T H17, Double-Negative and γδT cells
contribute to lupus nephritis.•T cell support autoantibody production in lymphoid and non-
lymphoid organs in SLE.•Aberrant activation of several pathways drives T cell malfunction in
SLE.•CaMKIV, ROCK, STAT3 AND PI3K/AKT/mTOR represent therapeutic targets.Systemic
Lupus Erythematosus is an autoimmune disorder caused by a complex combination of
genetic, epigenetic and environmental factors. Different polymorphisms and epigenetic …
contribute to lupus nephritis.•T cell support autoantibody production in lymphoid and non-
lymphoid organs in SLE.•Aberrant activation of several pathways drives T cell malfunction in
SLE.•CaMKIV, ROCK, STAT3 AND PI3K/AKT/mTOR represent therapeutic targets.Systemic
Lupus Erythematosus is an autoimmune disorder caused by a complex combination of
genetic, epigenetic and environmental factors. Different polymorphisms and epigenetic …
Highlights
- T cell transcriptomes can stratify patients.
- T H17, Double-Negative and γδT cells contribute to lupus nephritis.
- T cell support autoantibody production in lymphoid and non-lymphoid organs in SLE.
- Aberrant activation of several pathways drives T cell malfunction in SLE.
- CaMKIV, ROCK, STAT3 AND PI3K/AKT/mTOR represent therapeutic targets.
Systemic Lupus Erythematosus is an autoimmune disorder caused by a complex combination of genetic, epigenetic and environmental factors. Different polymorphisms and epigenetic modifications lead to altered gene expression and function of several molecules which lead to abnormal T cell responses. Metabolic and functional alterations result in peripheral tolerance failures and biased differentiation of T cells into pro-inflammatory and B cell-helper phenotypes as well as the accumulation of disease-promoting memory T cells. Understanding these T cell alterations and their origins is necessary to develop more accurate patient classification systems and to discover new therapeutic targets.
Elsevier