Sex, stroke, and inflammation: the potential for estrogen-mediated immunoprotection in stroke
RM Ritzel, LA Capozzi, LD McCullough - Hormones and behavior, 2013 - Elsevier
This article is part of a Special Issue" Hormones & Neurotrauma". Stroke is the third leading
cause of death and the primary cause of disability in the developed world. Experimental and
clinical data indicate that stroke is a sexually dimorphic disease, with males demonstrating
an enhanced intrinsic sensitivity to ischemic damage throughout most of their lifespan. The
neuroprotective role of estrogen in the female brain is well established, however, estrogen
exposure can also be deleterious, especially in older women. The mechanisms for this …
cause of death and the primary cause of disability in the developed world. Experimental and
clinical data indicate that stroke is a sexually dimorphic disease, with males demonstrating
an enhanced intrinsic sensitivity to ischemic damage throughout most of their lifespan. The
neuroprotective role of estrogen in the female brain is well established, however, estrogen
exposure can also be deleterious, especially in older women. The mechanisms for this …