Background Acute inflammatory reactions cause neuronal damage in cerebral ischemia-
reperfusion. Urinary trypsin inhibitor (UTI), a serine protease inhibitor, is cytoprotective
against ischemia-reperfusion injury in the liver, intestine, kidney, heart, and lung through its
antiinflammatory activity. Neuroprotective action of UTI on transient global cerebral ischemia
has been documented. This is the first study to determine whether UTI is neuroprotective
against transient focal cerebral ischemia. Methods Adult male Wistar rats were randomly …