Hypoxic-ischemic (HI) brain injury is frequently associated with premature and/or full-term
birth-related complications that reflect widespread damage to cerebral cortical structures.
Inflammation has been implicated in the long-term evolution and severity of HI brain injury.
Inter-Alpha Inhibitor Proteins (IAIPs) are immune modulator proteins that are reduced in
systemic neonatal inflammatory states. We have shown that endogenous IAIPs are present
in neurons, astrocytes and microglia and that exogenous treatment with human plasma …