[HTML][HTML] Inter-α-trypsin inhibitor, a covalent protein-glycosaminoglycan-protein complex
L Zhuo, VC Hascall, K Kimata - Journal of Biological Chemistry, 2004 - ASBMB
The inter-α-trypsin inhibitor (IαI) 1 family, a typical and classical example for protein-
glycosaminoglycan-protein (PGP) complexes, occurs constitutively in plasma at relatively
high concentrations and is a result of alternate combinations of three kinds of heavy chains
with a common light chain, the bikunin proteoglycan. The family is characterized by the
unique covalent linkage between the heavy chains and the chondroitin sulfate chain of
bikunin. The early studies on the IαI family molecules have largely focused on the light chain …
glycosaminoglycan-protein (PGP) complexes, occurs constitutively in plasma at relatively
high concentrations and is a result of alternate combinations of three kinds of heavy chains
with a common light chain, the bikunin proteoglycan. The family is characterized by the
unique covalent linkage between the heavy chains and the chondroitin sulfate chain of
bikunin. The early studies on the IαI family molecules have largely focused on the light chain …