Genomics of Alzheimer disease: a review
RN Rosenberg, D Lambracht-Washington, G Yu… - JAMA …, 2016 - jamanetwork.com
Importance To provide a comprehensive review of knowledge of the genomics of Alzheimer
disease (AD) and DNA amyloid β 42 (Aβ42) vaccination as a potential therapy. Observations
Genotype-phenotype correlations of AD are presented to provide a comprehensive
appreciation of the spectrum of disease causation. Alzheimer disease is caused in part by
the overproduction and lack of clearance of Aβ protein. Oligomer Aβ, the most toxic species
of Aβ, causes direct injury to neurons, accompanied by enhanced neuroinflammation …
disease (AD) and DNA amyloid β 42 (Aβ42) vaccination as a potential therapy. Observations
Genotype-phenotype correlations of AD are presented to provide a comprehensive
appreciation of the spectrum of disease causation. Alzheimer disease is caused in part by
the overproduction and lack of clearance of Aβ protein. Oligomer Aβ, the most toxic species
of Aβ, causes direct injury to neurons, accompanied by enhanced neuroinflammation …