Larazotide acetate regulates epithelial tight junctions in vitro and in vivo
S Gopalakrishnan, M Durai, K Kitchens, AP Tamiz… - Peptides, 2012 - Elsevier
Tight junctions (TJs) control paracellular permeability and apical-basolateral polarity of
epithelial cells, and can be regulated by exogenous and endogenous stimuli. Dysregulated
permeability is associated with pathological conditions, such as celiac disease and
inflammatory bowel disease. Herein we studied the mechanism by which larazotide acetate,
an 8-mer peptide and TJ regulator, inhibits the cellular changes elicited by gliadin
fragments, AT-1002, and cytokines. Previously, we demonstrated that AT-1002, a 6-mer …
epithelial cells, and can be regulated by exogenous and endogenous stimuli. Dysregulated
permeability is associated with pathological conditions, such as celiac disease and
inflammatory bowel disease. Herein we studied the mechanism by which larazotide acetate,
an 8-mer peptide and TJ regulator, inhibits the cellular changes elicited by gliadin
fragments, AT-1002, and cytokines. Previously, we demonstrated that AT-1002, a 6-mer …