[HTML][HTML] Integrin α2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen
O Holtkötter, B Nieswandt, N Smyth, W Muller… - Journal of Biological …, 2002 - ASBMB
The integrin α 2-subunit was ablated in mice by targeted deletion of the ITGA2 gene. α 2-
Deficient animals develop normally, are fertile, and reproduce. Surprisingly, no obvious
anatomical or histological differences were observed in mutant mice. Besides its
significance in tissue morphogenesis, integrin α 2 β 1 has been reported to play a major role
in hemostasis by mediating platelet adhesion and activation on subendothelial collagen. To
define its role in hemostasis, α 2-deficient platelets were analyzed for their capacity to …
Deficient animals develop normally, are fertile, and reproduce. Surprisingly, no obvious
anatomical or histological differences were observed in mutant mice. Besides its
significance in tissue morphogenesis, integrin α 2 β 1 has been reported to play a major role
in hemostasis by mediating platelet adhesion and activation on subendothelial collagen. To
define its role in hemostasis, α 2-deficient platelets were analyzed for their capacity to …