[HTML][HTML] The organization of a CSN5-containing subcomplex of the COP9 signalosome
GG Kotiguda, D Weinberg, M Dessau, C Salvi… - Journal of Biological …, 2012 - ASBMB
The COP9 signalosome (CSN) is an evolutionarily conserved multi-protein complex that
interfaces with the ubiquitin-proteasome pathway and plays critical developmental roles in
both animals and plants. Although some subunits are present only in an∼ 320-kDa complex-
dependent form, other subunits are also detected in configurations distinct from the 8-
subunit holocomplex. To date, the only known biochemical activity intrinsic to the complex,
deneddylation of the Cullin subunits from Cullin-RING ubiquitin ligases, is assigned to …
interfaces with the ubiquitin-proteasome pathway and plays critical developmental roles in
both animals and plants. Although some subunits are present only in an∼ 320-kDa complex-
dependent form, other subunits are also detected in configurations distinct from the 8-
subunit holocomplex. To date, the only known biochemical activity intrinsic to the complex,
deneddylation of the Cullin subunits from Cullin-RING ubiquitin ligases, is assigned to …