Targeting leukemia by CD1c-restricted T cells specific for a novel lipid antigen
Oncoimmunology, 2015•Taylor & Francis
A subset of CD1c-restricted T lymphocytes exhibits strong reactivity against leukemia cells.
These T cells recognize methyl-lysophosphatidic acid (mLPA), a novel lipid antigen
produced by acute leukemia cells. Considering that CD1c-restricted T cells display
efficacious anti-leukemia activities in a mouse model, this lipid antigen thus represents a
novel target in the immunotherapy of hematological malignancies.
These T cells recognize methyl-lysophosphatidic acid (mLPA), a novel lipid antigen
produced by acute leukemia cells. Considering that CD1c-restricted T cells display
efficacious anti-leukemia activities in a mouse model, this lipid antigen thus represents a
novel target in the immunotherapy of hematological malignancies.
A subset of CD1c-restricted T lymphocytes exhibits strong reactivity against leukemia cells. These T cells recognize methyl-lysophosphatidic acid (mLPA), a novel lipid antigen produced by acute leukemia cells. Considering that CD1c-restricted T cells display efficacious anti-leukemia activities in a mouse model, this lipid antigen thus represents a novel target in the immunotherapy of hematological malignancies.
Taylor & Francis Online