An EcR homolog from the filarial parasite, Dirofilaria immitis requires a ligand-activated partner for transactivation
C Shea, J Richer, G Tzertzinis, CV Maina - Molecular and biochemical …, 2010 - Elsevier
Filarial parasites are responsible for several serious human diseases with symptoms such
as lymphoedema, elephantiasis, and blindness. An understanding of how these parasites
pass through developmental checkpoints may suggest potential targets for intervention. A
useful model system for the study of the human parasites is the closely related nematode, D.
immitis, the causative agent of dog heartworm disease. Ecdysteroids have been identified in
filarial nematodes and have been shown to have a biological affect both on molting and …
as lymphoedema, elephantiasis, and blindness. An understanding of how these parasites
pass through developmental checkpoints may suggest potential targets for intervention. A
useful model system for the study of the human parasites is the closely related nematode, D.
immitis, the causative agent of dog heartworm disease. Ecdysteroids have been identified in
filarial nematodes and have been shown to have a biological affect both on molting and …