Why do worms need cholesterol?

TV Kurzchalia, S Ward - Nature cell biology, 2003 - nature.com
Nature cell biology, 2003nature.com
Cholesterol is a structural component of animal membranes that influences fluidity,
permeability and formation of lipid microdomains. It is also a precursor to signalling
molecules, including mammalian steroid hormones and insect ecdysones. The nematode
Caenorhabditis elegans requires too little cholesterol for it to have a major role in membrane
structure. Instead, its most probable signalling functions are to control molting and induce a
specialized non-feeding larval stage, although no cholesterol-derived signalling molecule …
Abstract
Cholesterol is a structural component of animal membranes that influences fluidity, permeability and formation of lipid microdomains. It is also a precursor to signalling molecules, including mammalian steroid hormones and insect ecdysones. The nematode Caenorhabditis elegans requires too little cholesterol for it to have a major role in membrane structure. Instead, its most probable signalling functions are to control molting and induce a specialized non-feeding larval stage, although no cholesterol-derived signalling molecule has yet been identified for these or any other functions.
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