[HTML][HTML] Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS
MD Beckler, JN Higginbotham, JL Franklin… - Molecular & cellular …, 2013 - ASBMB
Activating mutations in KRAS occur in 30% to 40% of colorectal cancers. How mutant KRAS
alters cancer cell behavior has been studied intensively, but non-cell autonomous effects of
mutant KRAS are less understood. We recently reported that exosomes isolated from mutant
KRAS-expressing colon cancer cells enhanced the invasiveness of recipient cells relative to
exosomes purified from wild-type KRAS-expressing cells, leading us to hypothesize mutant
KRAS might affect neighboring and distant cells by regulating exosome composition and …
alters cancer cell behavior has been studied intensively, but non-cell autonomous effects of
mutant KRAS are less understood. We recently reported that exosomes isolated from mutant
KRAS-expressing colon cancer cells enhanced the invasiveness of recipient cells relative to
exosomes purified from wild-type KRAS-expressing cells, leading us to hypothesize mutant
KRAS might affect neighboring and distant cells by regulating exosome composition and …