The most distinguishing feature of neurons is their capacity for regenerative electrical
activity. This activity imposes a significant mitochondrial burden, especially in neurons that
are autonomously active, have broad action potentials, and exhibit prominent Ca 2+ entry.
Many of the genetic mutations and toxins associated with Parkinson's disease compromise
mitochondrial function, providing a mechanistic explanation for the pattern of neuronal
pathology in this disease. Because much of the neuronal mitochondrial burden can be …