[HTML][HTML] Zinc protoporphyrin regulates cyclin D1 expression independent of heme oxygenase inhibition
P La, AP Fernando, Z Wang, A Salahudeen… - Journal of biological …, 2009 - ASBMB
Zinc protoporphyrin IX (ZnPP), an endogenous heme analogue that inhibits heme
oxygenase (HO) activity, represses tumor growth. It can also translocate into the nucleus and
up-regulate heme oxygenase 1 (HMOX1) gene expression. Here, we demonstrate that
tumor cell proliferation was inhibited by ZnPP, whereas tin protoporphyrin (SnPP), another
equally potent HO-1 inhibitor, had no effect. Microarray analysis on 128 tumorigenesis
related genes showed that ZnPP suppressed genes involved in cell proliferation and …
oxygenase (HO) activity, represses tumor growth. It can also translocate into the nucleus and
up-regulate heme oxygenase 1 (HMOX1) gene expression. Here, we demonstrate that
tumor cell proliferation was inhibited by ZnPP, whereas tin protoporphyrin (SnPP), another
equally potent HO-1 inhibitor, had no effect. Microarray analysis on 128 tumorigenesis
related genes showed that ZnPP suppressed genes involved in cell proliferation and …